Description

Cannabis works very well on our psychophysical balance. It is also true that, despite the reservations of pharmacy, more and more people are reaching for cannabis to help with conditions such as depression, anxiety and panic. In this lecture, Assoc. dr. Tanja Bagar emphasizes the importance of homeostasis and circadian rhythm for our psychological health.

Points he explains:

• CB1 and CB2, where are the receptors,
• low levels of inflammation, which are not detected through the CRP result, are addressed with CBD
• researching endocannabinoids is difficult because they break down quickly
• Enzymes, that we can form endocannabinoids, in some people there are defects of these enzymes and we can use molecules to influence the formation of our own cannabinoids, enzymes also for degradation (example of research on the FAAH enzyme for the degradation of CBD)
• when we interfere with the functioning of the EKS in drastic ways, the consequences are unpleasant. All cells have receptors for cannabinoids, they respond to them….even hair follicles have receptors.
• The Dangers of Synthetic Cannabinoids
• Homeostasis is the primary influence of EKS. When we have severe stress, trauma, we immediately take a high dose of CBD. Acute concussion. Fall, bad news, job loss. The body normally produces a huge amount of cannabinoids at these times.
• Circadian rhythm: we are cyclical beings, the secretion of hormones and neurotransmitters depends on this cycle, daily rhythm, internal clock, the coordination of our rhythm with the daily rhythm is important for our body, blue light, screens, internal clock confusion, insomnia, sleep problems, shifts at night (nurses who work at night are 40 times more likely to get cancer).
• Suprachismatic nuclei - a region inside the hypothalamus - the central biological clock, almost all tissues in the body have genes that respond to the circadian rhythm (it detects the intensity of light, if it is stronger, weaker, blue, red...after that, it coordinates when to produce melatonin, cortisol, etc)….EKS is the link between this center and the body's responses
• psyche and emotional state are dependent on hormones and neurotransmitters.
• fever- cannabinoids create a balance and consequently the temperature is regulated
• How we take care of EKS? Optimal conditions: essential fatty acids, microbiome and gut, as diverse as possible, microbiome diversity, avoiding drugs, toxins because this has long-term effects on EKS.
• How do psychiatrists in Slovenia view this? How do medications affect such conditions? Medicines trick the body into thinking that serotonin is elevated, when in fact it is not. EKS, however, remains in dysregulation.
• What are hedonic hot spots?
• The era of prohibition and research on cannabis and mental health. A big stigma.
• Psychiatric diagnoses and addictions.
• serotonin (deficiency leads to: OCD, impulsivity) and dopamine (deficiency leads to: Parkinson's, anhedonia), depression and insatiable hunger: serotonin and dopamine deficiency
• Using Cannabinoids to Cope with Stress to Avoid Psychiatric Diagnoses: prevention
• acute stress vs. chronic (physical changes in animals on adrenal glands, thymus reduced, less movement, less desire to find food, less desire to interact with others, typical depressed behavior. Also in the brain: decreased density of nerve cells in the prefrontal cortex. People with chronic depression show similar images of the brain.
• If CBD is used from stress, protects the body from physical damage, maintains homeostasis.
• After stress just as good performance, there is protection, but less than against stress. CBD stimulates the production of new neurons. 50-60% less cortisol under stress than without CBD.
• Low maintenance dose of 20-30-40 mg CBD per day
• CBD excellent antidepressant ….CBD is too anxiolytic
• How do common antidepressants work? Blocking the receptor. Trick. CBD, on the other hand, activates the cell to produce more of the hormone…it also binds to opiate receptors…
• Example brain tumor: a lot of depression...testing CBD on tumor growth and also on well-being...sentenced to 12 months to live...they were given the will to live, anti-depressant action, individual dosing.
• Anxiety not suitable for THC.
• Social phobias: a special region in the brain activates the production of GABA neurotransmitters (long-term use of cannabinoids)
• PTSD: fear control, over 70% oncology patients have PTSD because of the way doctors present the thing, the processing of memories in the brain….cannabis very effective, the right combination…repeatedly needed low dose THC, to activate CB1 receptors. 2:1 depending on the person, too much THC can potentiate fear
• Psychoses, schizophrenia, bipolar disorder
• Experience from Israel: THC is avoided in psychoses, CBD reduces psychoses.
• Addiction - neural pathway for reward - connection between the prefrontal cortex-nucleus accumbens-ventral tegmental area. Too excited this way and we want more. CBD helps with withdrawal symptoms. Because biochemistry returns to balance.
• Synthetic cannabinoids: very dangerous synthetic cannabinoids, huge number of deaths.
• Interaction with drugs: with most drugs in psychiatry, care must be taken when combining with CBD. Having compatible receptors and enzyme pathways, CBD can raise or lower blood medications. But combinations can be great if we know the effects.

Link to the lecture: https://biomons.com/konoplja-in-psiha/

We offer the possibility of a SHORT FREE CONSULTATION for an individual health condition when you do not know what is the best choice for you at: advice@biomons.com or call 040 614 617 (Darja Batista).

Asst. Dr. Tanja Bagar she is the director and, in this capacity, the president of the expert council of the International Cannabinoid Institute ICANNA. She is also the deputy director of a research, development and trade company and head of development and research in an environmental company. She is also active in the academic sphere. He teaches microbiology and ecoremediation topics at the faculty of Alma Mater Europaea and is a professional or collaborates scientifically with the Austrian College of Health and Development. She is a member of the Pomurska Academy of Sciences and Arts, the Slovenian Biochemical Society and the Society of Psychologists of Slovenia, and is one of the founders of the Society for the Preservation and Protection of the Environment. She has extensive research experience gained in laboratories at the National Institute of Chemistry, the Faculty of Biotechnology, the National Laboratory for Health, Environment and Nutrition, the Topolšica Hospital and the Institute of Microbiology and Genetics at the Georg-August University in Gottingen, Germany, and at To the Institute of Cell Biology, University of Edinburgh. Since 2013, she has participated as a reviewer in the national competition of research papers organized by the Association for Technical Culture of Slovenia. For social engagement, she received the Thanks of the Slovenian Microbiological Society for cooperation in the promotion of microbiology, a special recognition as part of the Slovenian award for social responsibility HORUS and an invitation to become an honorary member of the social cooperative KonopKo.

As a lecturer or listener, she participates in various conferences on cannabinoids and the endocannabinoid system, cannabis, nutrition, etc. at the national or international level. He deals with the microbiological aspect, cell biology, biochemistry and molecular biology in connection with the endocannabinoid system and the action of cannabinoids, laboratory analyzes of hemp products, etc. She completed the intensive four-week e-learning program Concepts of Cannabis Science I conducted by Kenevir Research (Oregon, USA), as well as the advanced program Concepts of Cannabis Science II

Tanja Bagar, winner of the prize for talented students during her studies, graduated from the study of microbiology at the Faculty of Biotechnology of the University of Ljubljana and received the Prešeren Prize for her thesis. She continued her postgraduate studies at the Faculty of Medicine in Ljubljana, where she obtained her doctorate in the field of biomedical sciences. As a young researcher, she received the Krka Award for special achievements in the field of research work, and a municipal gold plaque for successfully completing her doctorate. She passed the professional exam at the Ministry of Health.

Tjaša Korelc she is an anthropologist with a university degree, consultant in western natural medicine (spagiria and alchemy)

She is a cultural and social anthropologist by education, and at the same time she attended a school of spagyria and alchemy, traditional Western medicine, in Italy. She also obtained a cannabinoid counseling certificate from Dr. to Dustin Sulak (online) and is a professional associate at Biomons.